heteroalkyl oxime derivative can cause damage to bacterial dna

the present study aimed to evaluate the antimicrobial activity of a hetroalkyl oximec synthetic compoundderivative (benzophenone o-4-bromoethyl oxime) against two gram positive and three gram negative bacteria.the antibacterial characteristic of this compound was shown using the circular zone diameter of bacterial growthinhibition by disk-diffusion method. in addition, the random amplified polymorphic dna (rapd) techniqueusing twenty-three primers was performed to investigate the dna polymorphism of bacteria that were affected bythe synthetic chemical drug. among these, only 18 primers were found efficient for reproducible banding pattern.disappearance or appearance of bands between controls and treatments confirm rearrangements and dnadamages in the priming binding sites of bacterial genome. the results show that the rapd method can be a usefulidentification tool for studying the dna polymorphism created by synthetic chemical drugs. the results obtainedwith this technique showed significant differences between the rapd profiles.